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Ready-To-Use Indicators

Irreversible Heat and Reversible 18°C Indicators


Heat exposure can degrade the efficacy of many temperature-sensitive medical products, such as vaccines and biologics.  Even a gradual change in temperature of a product over time can affect the performance. Products such as injectable medications, adhesives and sealants require refrigeration to maintain their efficacy, but are recommended for use at room temperature for optimal performance.

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Visual Indication of Heat Exposure or Room Temperature

Zebra offers irreversible and reversible indicators that support a variety of different stability profiles, helping you monitor temperature to ensure a positive customer experience. Apply Zebra HEATmarker™ time-temperature indicators to monitor heat exposure over time.  Apply LIMITmarker™ irreversible threshold heat indicators to monitor immediate or prolonged exposure at or beyond a threshold temperature. Improve the user experience with LIMITmarker Reversible 18⁰C to indicate when an item requiring refrigerated storage approaches room temperature.

Time-Temperature Indicators

HEATmarker™

HEATmarker is a miniaturized, self-adhesive temperature monitoring indicator that can be applied directly to temperature-sensitive products. HEATmarker gradually changes color as heat exposure accumulates. When the gradual color change surpasses the reference color the user can identify if the product has exceeded its temperature limit.

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